⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406830 | 0.74 | — | — | |
| SCHEMBL193743 | 0.74 | — | — | |
| SCHEMBL18668181 | 0.70 | — | — | |
| SCHEMBL2799371 | 0.70 | — | — | |
| SCHEMBL2687101 | 0.70 | — | — | |
| SCHEMBL9098933 | 0.70 | — | — | |
| SCHEMBL3056334 | 0.70 | — | — | |
| SCHEMBL14694175 | 0.65 | — | — | |
| SCHEMBL2794625 | 0.63 | SIRT6 (0.52) | — | |
| SCHEMBL18938691 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295157-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2023-09-21 | — | — | US | claimed |
| CN-116134035-A | 3- (1H-imidazol-2-yl) -2,3,8 a-tetrahydroindol-5 (1H) -one derivatives useful as factor XIA inhibitors | 詹森药业有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-117177974-A | Imidazole-containing condensed ring derivative, preparation method and medical application thereof | 长春金赛药业有限责任公司 | 2023-12-05 | — | — | CN | disclosed |
| US-20230295157-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2023-09-21 | — | — | US | disclosed |
| EP-4185588-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | Janssen Pharmaceutica NV (BE) | 2023-05-31 | — | — | EP | disclosed |
| CN-116134035-A | 3- (1H-imidazol-2-yl) -2,3,8 a-tetrahydroindol-5 (1H) -one derivatives useful as factor XIA inhibitors | 詹森药业有限公司 | 2023-05-16 | — | — | CN | disclosed |
| US-10568326-B2 | 5-substituted imidazole derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-02-25 | — | — | US | disclosed |
| EP-3277674-B1 | TRIAZOL DERIVATIVES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2019-09-11 | — | — | EP | disclosed |
| US-20190223437-A1 | ACTIVE COMPOUND COMBINATIONS COMPRISING A 5-SUBSTITUTED IMIDAZOLE DERIVATIVE | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-07-25 | — | — | US | disclosed |
| US-20190082691-A1 | NOVEL 5-SUBSTITUTED IMIDAZOLE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-03-21 | — | — | US | disclosed |
| US-10231453-B2 | 5-substituted imidazole derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-03-19 | — | — | US | disclosed |
| EP-2984082-B1 | NOVEL TRIAZOLE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2017-08-02 | — | — | EP | disclosed |
| US-9668481-B2 | Triazole derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9550752-B2 | Triazolinthione derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-01-24 | — | — | US | disclosed |
| US-20160068516-A1 | NOVEL TRIAZOLE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-03-10 | — | — | US | disclosed |
| US-20160050928-A1 | NOVEL TRIAZOLE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-02-25 | — | — | US | disclosed |
| US-20160031851-A1 | NOVEL TRIAZOLINTHIONE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-02-04 | — | — | US | disclosed |
| WO-2012037282-A3 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| EP-2297136-B1 | INSECTICIDAL PYRIDYLPIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2324010-B1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-11-30 | — | — | EP | disclosed |