Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.81 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.56 |
| ▸ | STK3 | Q13188 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | AKT2 | P31751 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722249 | 0.91 | ROCK2 (0.87) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL1724850 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| Trifluoroacetic Acid SCHEMBL1723799 | 0.87 | ROCK2 (0.81) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL876581 | 0.87 | ROCK2 (0.70) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL3795144 | 0.85 | ROCK2 (0.61) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL11919876 | 0.85 | PRKD3 (0.77) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL877371 | 0.85 | ROCK2 (1.00) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL3798011 | 0.83 | ROCK2 (0.58) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL20953095 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL20953067 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1PRKD3CSNK2A1STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |