Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 17/20 | 0.91 |
| ▸ | PIK3CD known ✓ | O00329 | 1/20 | 0.83 |
| ▸ | PIK3CB known ✓ | P42338 | 1/20 | 0.83 |
| ▸ | PIK3CG known ✓ | P48736 | 1/20 | 0.83 |
| ▸ | ATM | Q13315 | 19/20 | 0.91 |
| ▸ | MTOR | P42345 | 18/20 | 0.91 |
| ▸ | ATR | Q13535 | 5/20 | 0.91 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.84 |
| ▸ | PRKDC | P78527 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17272539 | 1.00 | ATM (0.91) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17246341 | 0.96 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17242588 | 0.96 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17246304 | 0.96 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17272548 | 0.94 | ATM (0.91) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17241780 | 0.91 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL17246359 | 0.91 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL20006498 | 0.91 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL29355614 | 0.91 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 | |
| SCHEMBL30410610 | 0.91 | ATM (1.00) | ATMMTORPIK3CAATRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185468-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA UK LIMITED (GB) | 2019-06-20 | — | — | US | disclosed |
| US-10189834-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer | ASTRAZENECA AB (SE) | 2019-01-29 | — | — | US | disclosed |
| US-20180134699-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA UK LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| EP-3140303-B1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| US-9822111-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer | ASTRAZENECA AB (SE) | 2017-11-21 | — | — | US | disclosed |
| US-20160368920-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA AB (SE) | 2016-12-22 | — | — | US | disclosed |
| US-9428503-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating Cancer | ASTRAZENECA AB (SE) | 2016-08-30 | — | — | US | disclosed |
| US-20150336952-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA AB (SE) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134699-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | PIK3CA 229/4885PIK3CD 443/4885PIK3CB 469/4885 |
| US-20190185468-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | PIK3CA 229/4885PIK3CD 443/4885PIK3CB 469/4885 |
| US-20160368920-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | PIK3CA 229/4885PIK3CD 443/4885PIK3CB 469/4885 |
| US-20150336952-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, CHEK2, CHEK1 | PIK3CA 229/4885PIK3CD 443/4885PIK3CB 469/4885 |
| US-10189834-B2 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer | ATM, CHEK2, CHEK1 | PIK3CA 229/4885PIK3CD 443/4885PIK3CB 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.