Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078340 | 1.00 | NAAA (0.66) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL11402799 | 0.91 | DRD3 (0.53) | NAAAOPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL4077695 | 0.85 | MEN1 (0.58) | DRD3CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL9596982 | 0.80 | OPRM1 (0.44) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL17274421 | 0.79 | NAAA (1.00) | NAAAOPRM1OPRD1OPRK1DRD3 | |
| SCHEMBL24238319 | 0.78 | OPRM1 (0.54) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL24238338 | 0.78 | OPRM1 (0.54) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL24238344 | 0.77 | OPRM1 (0.42) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL24238281 | 0.77 | OPRM1 (0.42) | NAAAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL17279134 | 0.76 | NAAA (0.58) | NAAAOPRM1OPRD1OPRK1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640494-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NORTHEASTERN UNIVERSITY (US) | 2020-05-05 | — | — | US | disclosed |
| US-20180222894-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2018-08-09 | — | — | US | disclosed |
| US-20180222894-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2018-08-09 | — | — | US | disclosed |
| US-9963444-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NORTHEASTERN UNIVERSITY (US) | 2018-05-08 | — | — | US | disclosed |
| US-9963444-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NORTHEASTERN UNIVERSITY (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2017-04-27 | — | — | US | disclosed |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2017-04-27 | — | — | US | disclosed |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NORTHEASTERN UNIVERSITY | 2017-04-27 | — | — | US | disclosed |
| EP-3145505-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | Northeastern University (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179190-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | NORTHEASTERN UNIVERSITY (US) | 2015-11-26 | — | — | WO | disclosed |
| WO-2015179190-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | NORTHEASTERN UNIVERSITY (US) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222894-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NAAA, NAT1, NAALAD2 | NAAA 1/4885OPRM1 1995/4885OPRD1 3874/4885 |
| US-10640494-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof | NAAA, NAT1, NAALAD2 | NAAA 1/4885OPRM1 1995/4885OPRD1 3874/4885 |
| US-20170114050-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Their Use Thereof | NAAA, NAT1, NIT2 | NAAA 1/4885OPRM1 2241/4885OPRD1 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.