Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16635990 | 0.98 | L3MBTL1 (0.50) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL351170 | 0.98 | L3MBTL1 (0.50) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL30565589 | 0.98 | L3MBTL1 (0.50) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL5798270 | 0.96 | CYP3A4 (0.48) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL6693951 | 0.96 | L3MBTL1 (0.52) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL6649771 | 0.94 | CYP3A4 (0.47) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL166826 | 0.94 | L3MBTL1 (0.54) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL30185055 | 0.94 | L3MBTL1 (0.54) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL29390114 | 0.94 | L3MBTL1 (0.54) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL30185058 | 0.94 | L3MBTL1 (0.54) | CYP3A4L3MBTL1HSP90AA1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969759-B2 | Duplex-selective organometallic DNA intercalators | NORTHWESTERN UNIVERSITY (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170082614-A1 | DUPLEX-SELECTIVE ORGANOMETALLIC DNA INTERCALATORS | NORTHWESTERN UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
| WO-2015179736-A1 | DUPLEX-SELECTIVE ORGANOMETALLIC DNA INTERCALATORS | NORTHWESTERN UNIVERSITY (US) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170082614-A1 | DUPLEX-SELECTIVE ORGANOMETALLIC DNA INTERCALATORS | POLRMT, POLM, SSBP1 | CYP3A4 2757/4885L3MBTL1 186/4885HSP90AA1 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.