Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18716984 | 0.86 | GAA (0.49) | GAAALDH1A1LMNAPKMCYP1A2 | |
| SCHEMBL14763361 | 0.79 | GAA (0.73) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL17440158 | 0.79 | GAA (0.73) | GAAALDH1A1CYP1A2CYP2C9RECQL | |
| SCHEMBL17275882 | 0.78 | CRBN (0.32) | CRBN | |
| SCHEMBL17275853 | 0.76 | GAA (0.39) | GAAALDH1A1LMNAPKMCYP1A2 | |
| SCHEMBL23921490 | 0.74 | GAA (0.57) | GAAALDH1A1RECQL | |
| SCHEMBL19437622 | 0.74 | CRBN (0.32) | CRBN | |
| SCHEMBL19437517 | 0.74 | CRBN (0.32) | CRBN | |
| SCHEMBL28529745 | 0.74 | GAA (0.53) | GAAALDH1A1LMNAPKMCYP1A2 | |
| SCHEMBL18716962 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145552-B1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2020-03-04 | — | — | EP | disclosed |
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2019-09-10 | — | — | US | disclosed |
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2019-09-10 | — | — | US | disclosed |
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-04-06 | — | — | US | disclosed |
| EP-3145552-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | Novartis AG (CH) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179734-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| WO-2015179734-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | PDIA6, PDIA3, KRTCAP2 | GAA 4216/4885ALDH1A1 490/4885CRBN 204/4885 |
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | PDIA6, PDIA3, KRTCAP2 | GAA 4216/4885ALDH1A1 490/4885CRBN 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.