PDIA3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL7628574	0.33	3/20
SCHEMBL7637697	0.33	3/20
SCHEMBL3957917	0.62	2/20
SCHEMBL3961735	0.62	2/20
SCHEMBL4622327	0.42	2/20
SCHEMBL4622330	0.42	2/20
SCHEMBL4959831	0.42	2/20
SCHEMBL4959838	0.42	2/20
SCHEMBL2454844	0.41	2/20
SCHEMBL2454848	0.41	2/20
SCHEMBL1764410	0.41	2/20
SCHEMBL1764411	0.41	2/20
SCHEMBL7784472	0.35	2/20
SCHEMBL7633252	0.32	2/20
SCHEMBL7637705	0.32	2/20
SCHEMBL7784492	0.32	2/20
SCHEMBL7789896	0.32	2/20
SCHEMBL7789970	0.32	2/20
SCHEMBL7790428	0.32	2/20
Juglone (SCHEMBL34185)	1.00	1/20

Clinical trials — most relevant to PDIA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Comparative and Efficacy Study of ACTHar Gel Alone or in Combination With Tacrolimus in Fibrillary Glomerulopathy	PHASE4	WITHDRAWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity	PHASE2	RECRUITING
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma	PHASE2	RECRUITING
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Quantification of GADD34 Expression in RA	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)	nan	RECRUITING
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Effect of ORI-guided Oxygen Titration on Oxidative Stress in Rhinoplasty Surgery	nan	COMPLETED
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Effect of Mepolizumab on Severe Eosinophilic Asthma	nan	UNKNOWN
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia	nan	COMPLETED
Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative Neoplasms	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING
Efficacy of Solarplast for Health and Oxidative Stress	nan	COMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers	nan	COMPLETED
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy	nan	ACTIVE_NOT_RECRUITING
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a PDIA3 binder may also engage these)

Protein	Name	Similarity
Q4VIT4	—	1.000	Q4VIT4 →
P38657	—	1.000	P38657 →
Q5RDG4	—	1.000	Q5RDG4 →
P11598	—	1.000	P11598 →
P27773	—	1.000	P27773 →
PDIA4	Protein disulfide-isomerase A4	0.995	landscape →
Q8JG64	—	0.995	Q8JG64 →
Q29RV1	—	0.994	Q29RV1 →
P08003	—	0.994	P08003 →
Q53LQ0	—	0.992	Q53LQ0 →
Q5R5B6	—	0.992	Q5R5B6 →
Q43116	—	0.992	Q43116 →
P38659	—	0.991	P38659 →
Q9XI01	—	0.991	Q9XI01 →
P29828	—	0.991	P29828 →
P4HB	Protein disulfide-isomerase	0.990	landscape →
P34329	—	0.989	P34329 →
Q2HWU2	—	0.989	Q2HWU2 →
P38661	—	0.989	P38661 →
P04785	—	0.988	P04785 →
P05307	—	0.988	P05307 →
P09102	—	0.988	P09102 →
P80284	—	0.988	P80284 →
P09103	—	0.988	P09103 →
Q8R4U2	—	0.988	Q8R4U2 →
Q9XF61	—	0.988	Q9XF61 →
Q67IX6	—	0.987	Q67IX6 →
Q17770	—	0.986	Q17770 →
P54399	—	0.986	P54399 →
Q9SRG3	—	0.985	Q9SRG3 →