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PDIA6

Protein disulfide-isomerase A6 · Q15084 · PDIA6 on Sugi Atlas →

1,129 patent compounds predicted against PDIA6, 569 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL21064814 SCHEMBL21064814 1.00 3/20
SCHEMBL21064816 SCHEMBL21064816 1.00 3/20
SCHEMBL21064818 SCHEMBL21064818 1.00 3/20
SCHEMBL21064820 SCHEMBL21064820 1.00 3/20
SCHEMBL21064822 SCHEMBL21064822 1.00 3/20
SCHEMBL21100872 SCHEMBL21100872 1.00 3/20
SCHEMBL21100878 SCHEMBL21100878 1.00 3/20
SCHEMBL21100897 SCHEMBL21100897 1.00 3/20
SCHEMBL21100899 SCHEMBL21100899 1.00 3/20
SCHEMBL25997795 SCHEMBL25997795 1.00 3/20
SCHEMBL21100898 SCHEMBL21100898 0.89 3/20
SCHEMBL21100901 SCHEMBL21100901 0.89 3/20
SCHEMBL21101058 SCHEMBL21101058 0.86 3/20
SCHEMBL25997758 SCHEMBL25997758 0.85 3/20
SCHEMBL21100877 SCHEMBL21100877 0.79 3/20
SCHEMBL22030255 SCHEMBL22030255 0.79 3/20
SCHEMBL22030257 SCHEMBL22030257 0.79 3/20
SCHEMBL25997759 SCHEMBL25997759 0.79 3/20
SCHEMBL25997760 SCHEMBL25997760 0.79 3/20
SCHEMBL21100879 SCHEMBL21100879 0.78 3/20

Clinical trials — most relevant to PDIA6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes PHASE4UNKNOWN
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Evaluation of the Possible Safety and Efficacy of Dapagliflozin in the Prophylaxis of Doxorubicin-Induced Cardiotoxicity PHASE2RECRUITING
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Phase I Study of Novel Estrogen Receptor(ER) a36 Modifier Icaritin in Advanced Breast Cancer Patients PHASE1UNKNOWN
Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration PHASE1COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
PBA Use for Treatment of ATF6-/- Patients EARLY_PHASE1SUSPENDED
Quantification of GADD34 Expression in RA nanCOMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility nanCOMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia nanCOMPLETED
Albumin Catabolic Rate Measured by a Stable Isotope nanNOT_YET_RECRUITING
Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) nanCOMPLETED
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Endoplasmic Reticulum Stress and Resistance to Treatments in Ph-negative Myeloproliferative Neoplasms nanCOMPLETED
Shwachman Diamond Syndrome Registry and Study nanRECRUITING
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Parkinson's Disease nanWITHDRAWN
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease nanWITHDRAWN
Effect of Protein on Endoplasmic Reticulum Stress nanNOT_YET_RECRUITING
Effect of Mepolizumab on Severe Eosinophilic Asthma nanUNKNOWN
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy nanACTIVE_NOT_RECRUITING
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection nanUNKNOWN
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PDIA6 binder may also engage these)

ProteinNameSimilarity
Q922R8 — 1.000 Q922R8 →
Q5R6T1 — 0.999 Q5R6T1 →
P38660 — 0.999 P38660 →
Q63081 — 0.997 Q63081 →
Q11067 — 0.993 Q11067 →
Q9V438 — 0.989 Q9V438 →
PDIA3 Protein disulfide-isomerase A3 0.985 landscape →
Q5RDG4 — 0.985 Q5RDG4 →
Q9MAU6 — 0.984 Q9MAU6 →
P38657 — 0.981 P38657 →
O48773 — 0.981 O48773 →
Q4VIT4 — 0.980 Q4VIT4 →
P05307 — 0.980 P05307 →
P09102 — 0.980 P09102 →
P38659 — 0.979 P38659 →
P27773 — 0.978 P27773 →
Q8JG64 — 0.978 Q8JG64 →
PDIA4 Protein disulfide-isomerase A4 0.977 landscape →
P11598 — 0.977 P11598 →
Q8R4U2 — 0.977 Q8R4U2 →
Q53LQ0 — 0.977 Q53LQ0 →
Q00216 — 0.977 Q00216 →
Q17770 — 0.975 Q17770 →
Q921X9 — 0.975 Q921X9 →
P4HB Protein disulfide-isomerase 0.975 landscape →
P08003 — 0.974 P08003 →
Q5R5B6 — 0.973 Q5R5B6 →
Q2HWU2 — 0.973 Q2HWU2 →
Q92249 — 0.973 Q92249 →
P80284 — 0.972 P80284 →