Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 7/20 | 0.37 |
| ▸ | RARG | P13631 | 7/20 | 0.37 |
| ▸ | RXRA | P19793 | 4/20 | 0.37 |
| ▸ | RARA | P10276 | 7/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276900 | 0.79 | CYP2D6 (0.39) | OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL17276832 | 0.79 | CYP2D6 (0.39) | OPRD1KCNH2CYP2D6OPRK1 | |
| SCHEMBL3837866 | 0.74 | OPRD1 (0.42) | OPRD1KCNH2CYP2D6TDP2RXRA | |
| SCHEMBL3836335 | 0.70 | OPRD1 (0.36) | OPRD1KCNH2CYP2D6TDP2RARG | |
| Hydrochloric Acid SCHEMBL1814403 | 0.70 | OPRD1 (0.36) | OPRD1KCNH2CYP2D6TDP2RARB | |
| SCHEMBL4272876 | 0.67 | TP53 (0.35) | OPRD1KCNH2RARBOPRK1 | |
| SCHEMBL1823244 | 0.67 | BACE1 (0.42) | OPRD1 | |
| SCHEMBL12761461 | 0.66 | HDAC3 (0.54) | OPRD1KCNH2CYP2D6OPRK1OPRM1 | |
| SCHEMBL17276802 | 0.66 | HDAC3 (0.50) | — | |
| SCHEMBL16334838 | 0.66 | IL2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145933-A1 | NAMPT INHIBITORS AND METHODS | Genzyme Corporation (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179759-A1 | NAMPT INHIBITORS AND METHODS | GENZYME CORPORATION (US) | 2015-11-26 | — | — | WO | disclosed |