Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 5/20 | 0.38 |
| ▸ | BCR | P11274 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627 | 0.96 | F9 (0.38) | F9ABL1BCRMAPTRAB9A | |
| SCHEMBL17277485 | 0.89 | KMT2A (0.42) | F9ABL1BCRRAB9AF10 | |
| SCHEMBL12062045 | 0.89 | F9 (0.37) | F9ABL1BCRMAPTRAB9A | |
| SCHEMBL17277467 | 0.87 | FLT3 (0.42) | F9MAPK8 | |
| SCHEMBL12061813 | 0.85 | F10 (0.39) | F9MAPTRAB9AF10LMNA | |
| SCHEMBL20019807 | 0.85 | — | — | |
| SCHEMBL17277314 | 0.85 | PARP1 (0.32) | MAPTRAB9AF10POLBPARP1 | |
| SCHEMBL12075213 | 0.84 | MEN1 (0.39) | F9F10MEN1KMT2ACHUK | |
| SCHEMBL17484562 | 0.84 | LMNA (0.38) | F9F10POLBLMNACHUK | |
| SCHEMBL17277412 | 0.82 | ALDH1A1 (0.40) | MAPTPOLBLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488525-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |