Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062286 | 0.81 | USP2 (0.37) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL8259789 | 0.76 | HRH3 (0.40) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL15332627 | 0.76 | MAPK1 (0.38) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL8807732 | 0.76 | ADRA2C (0.41) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL15331710 | 0.74 | MAPK1 (0.35) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL14168524 | 0.74 | USP2 (0.40) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL29604163 | 0.74 | USP2 (0.40) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL22770859 | 0.74 | USP2 (0.40) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL30929646 | 0.74 | USP2 (0.40) | LMNAMAOASLC6A2PKMUSP2 | |
| SCHEMBL5782684 | 0.73 | USP2 (0.39) | LMNAMAOASLC6A2PKMUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488525-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |