Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18731484 | 0.77 | AAK1 (0.47) | AAK1LMNARXFP1NCEH1SMN1; SMN2 | |
| SCHEMBL13560993 | 0.73 | AAK1 (0.40) | AAK1LMNARXFP1NCEH1MAPK1 | |
| SCHEMBL12294841 | 0.73 | AAK1 (0.40) | AAK1LMNARXFP1NCEH1MAPK1 | |
| SCHEMBL19488525 | 0.71 | CYP26A1 (0.40) | AAK1LMNAMAPK1 | |
| SCHEMBL19488870 | 0.70 | CASR (0.44) | LMNASMN1; SMN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL12299034 | 0.69 | ALDH1A1 (0.50) | RXFP1NCEH1MAPT | |
| SCHEMBL12327655 | 0.69 | LMNA (0.57) | LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL19488521 | 0.69 | ALDH1A1 (0.40) | SMN1; SMN2MAPT | |
| SCHEMBL15043000 | 0.69 | NCEH1 (0.49) | LMNARXFP1NCEH1SMN1; SMN2L3MBTL1 | |
| SCHEMBL19488517 | 0.68 | ALDH1A1 (0.41) | SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545060-B1 | FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2015-11-25 | — | — | EP | disclosed |