SCHEMBL17277754

SCHEMBL17277754

CC(=O)c1ccc2cc[nH]c(=O)c2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.54
ROCK2 O75116 6/20 0.49
ALDH1A1 P00352 2/20 0.49
HPGD P15428 2/20 0.49
MAPT P10636 1/20 0.49
PARP1 P09874 1/20 0.47
MAPK14 Q16539 2/20 0.46
MAOA P21397 1/20 0.43
CYP2A6 P11509 1/20 0.43
CHEK1 O14757 2/20 0.42
KDM4E B2RXH2 1/20 0.42
ENPP2 Q13822 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PLK4 O00444 1/20 0.41
DCLK1 O15075 1/20 0.41
PRKD3 O94806 1/20 0.41
MAP4K4 O95819 1/20 0.41
PAK4 O96013 1/20 0.41
CHEK2 O96017 1/20 0.41
INSR P06213 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30159472 0.84 KDM4E (0.61) ROCK2ALDH1A1HPGDPARP1MAPK14
SCHEMBL1145075 0.84 KDM4E (0.61) ROCK2ALDH1A1HPGDPARP1MAPK14
SCHEMBL30159669 0.82 KDM4E (0.48) ROCK2ALDH1A1HPGDPARP1MAPK14
SCHEMBL12647234 0.82 MAPK14 (0.44) ROCK2ALDH1A1HPGDMAPTPARP1
SCHEMBL12663938 0.82 MAPK14 (0.44) SLC2A1ROCK2ALDH1A1HPGDPARP1
SCHEMBL2116289 0.82 KDM4E (0.48) ROCK2ALDH1A1HPGDPARP1MAPK14
SCHEMBL2118663 0.80 MAPK14 (0.50) ROCK2PARP1MAPK14CHEK1
SCHEMBL4856004 0.78 ROCK2 (0.43) SLC2A1ROCK2ALDH1A1HPGDPARP1
SCHEMBL121922 0.77 ALDH1A1 (0.70) ALDH1A1HPGDMAPTMAOACYP2A6
SCHEMBL1038250 0.74 PARP1 (0.53) ROCK2ALDH1A1HPGDPARP1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2947082-A1 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS Pfizer Inc (US) 2015-11-25 EP disclosed