Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.36 |
| ▸ | CA1 | P00915 | 7/20 | 0.36 |
| ▸ | CA2 | P00918 | 7/20 | 0.36 |
| ▸ | CA9 | Q16790 | 7/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708671 | 0.96 | CA12 (0.33) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL19451363 | 0.93 | CRBN (0.34) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL29427447 | 0.90 | TDP1 (0.32) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL31328769 | 0.90 | CRBN (0.33) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL29427494 | 0.90 | TDP1 (0.32) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL21071149 | 0.84 | TDP1 (0.43) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL28656359 | 0.84 | TDP1 (0.43) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL13759224 | 0.84 | TDP1 (0.43) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL17739953 | 0.84 | TDP1 (0.43) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL31395584 | 0.84 | TDP1 (0.43) | CA12CA1CA2CA9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | NOVARTIS AG (CH) | 2019-09-10 | — | — | US | disclosed |
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-04-06 | — | — | US | disclosed |
| WO-2015179734-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | NOVARTIS AG (CH) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095572-A1 | METHODS FOR MAKING CONJUGATES FROM DISULFIDE-CONTAINING PROTEINS | PDIA6, PDIA3, KRTCAP2 | CA12 462/4885CA1 278/4885CA2 1995/4885 |
| US-10406198-B2 | Methods for making conjugates from disulfide-containing proteins | PDIA6, PDIA3, KRTCAP2 | CA12 462/4885CA1 278/4885CA2 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.