Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17282253 | 0.85 | MAPT (0.44) | MAPTKMT2AMEN1HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL3045694 | 0.84 | CSNK2A1 (0.47) | KMT2ALMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL12505436 | 0.83 | ALDH1A1 (0.46) | MAPTKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL15771601 | 0.82 | MAPT (0.43) | MAPTKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL30843149 | 0.82 | ALDH1A1 (0.57) | MAPTKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL3388103 | 0.81 | TSHR (0.53) | MAPTKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL29488334 | 0.81 | TSHR (0.53) | MAPTKMT2AMEN1HSD17B10LMNA | |
| SCHEMBL17282266 | 0.80 | KMT2A (0.50) | MAPTKMT2AMEN1HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL3054376 | 0.78 | LMNA (0.57) | MAPTKMT2AMEN1LMNATSHR | |
| SCHEMBL14692447 | 0.77 | TSHR (0.46) | MAPTKMT2AMEN1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |