SCHEMBL17285035

SCHEMBL17285035

CNc1ccccc1C(N)c1cccc(C#N)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCDIN3D Q7Z5W3 3/20 0.40
ADORA2A P29274 2/20 0.36
ADORA1 P30542 2/20 0.36
ADORA2B P29275 1/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
TNF P01375 1/20 0.36
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
MAPK1 P28482 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
S1PR1 P21453 1/20 0.35
GRM4 Q14833 1/20 0.35
GPR139 Q6DWJ6 1/20 0.34
HPGDS O60760 1/20 0.34
HDAC1 Q13547 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17196263 0.79 KDM4E (0.40) ADORA2AADORA1ALDH1A1KDM4EGAA
SCHEMBL22927645 0.76 TSHR (0.48) ADORA2AADORA1ALDH1A1TNFGRM4
SCHEMBL29434770 0.76 TSHR (0.48) ADORA2AADORA1ALDH1A1TNFGRM4
Hydrochloric Acid SCHEMBL29908241 0.75 TSHR (0.46) ADORA2AADORA1ALDH1A1TNFGRM4
SCHEMBL30554313 0.71 GLA (0.44) ALDH1A1TNFCLK4S1PR1GRM4
SCHEMBL1719895 0.71 GLA (0.44) ALDH1A1TNFCLK4S1PR1GRM4
SCHEMBL1002822 0.71 GLA (0.44) ALDH1A1TNFCLK4S1PR1GRM4
SCHEMBL5861621 0.71 GLA (0.44) ALDH1A1TNFCLK4S1PR1GRM4
SCHEMBL2939744 0.70 GRM4 (0.44) ALDH1A1TNFCLK4S1PR1GRM4
Hydrochloric Acid SCHEMBL1669311 0.70 ADRA1D (0.44) ALDH1A1TNFCLK4S1PR1GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015178732-A1 MULTI-COMPONENT HOST MATERIAL AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2015-11-26 WO disclosed