Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 12/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.40 |
| ▸ | BUB1 | O43683 | 4/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.36 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.36 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541331 | 0.87 | ADORA2B (0.45) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL796431 | 0.76 | ADORA2B (0.58) | ADORA2BADORA3ADORA2AADORA1RPS6KA3 | |
| SCHEMBL30495481 | 0.76 | ADORA2B (0.58) | ADORA2BADORA3ADORA2AADORA1RPS6KA3 | |
| SCHEMBL1723697 | 0.76 | ADORA2B (0.52) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL1546641 | 0.75 | ADORA2B (0.56) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL1546784 | 0.73 | ADORA2B (0.41) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL8979404 | 0.72 | ADORA2B (0.49) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL2686093 | 0.70 | HSD17B10 (0.48) | KLKB1 | |
| SCHEMBL1546781 | 0.70 | KLKB1 (0.52) | ADORA2BADORA3ADORA2AADORA1KLKB1 | |
| SCHEMBL1546107 | 0.70 | ADORA2B (0.54) | ADORA2BADORA3ADORA2AADORA1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |