Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | GLA | P06280 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | STAT6 | P42226 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455085 | 0.97 | TOP1 (0.94) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL4557415 | 0.97 | TOP1 (0.94) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL4453581 | 0.95 | TOP1 (0.90) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL27588707 | 0.94 | TOP1 (0.89) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL24513849 | 0.93 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL27606708 | 0.92 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL11070279 | 0.92 | TOP1 (0.86) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL7976653 | 0.92 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL23432536 | 0.92 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA | |
| Cositecan SCHEMBL15692672 | 0.92 | TOP1 (0.85) | TOP1MEN1KMT2AALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653319-B1 | Formulating alkaline supersaturated aqueous solution of lipophilic derivative and solubilizer; acidifying | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2003-11-25 | — | — | US | claimed |
| US-20240156808-A1 | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | EDISON ONCOLOGY (US) | 2024-05-16 | — | — | US | disclosed |
| EP-4297746-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED COMPOUNDS AND THERAPIES FOR THE TREATMENT OF DISEASES | Edison Oncology (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-1638978-B1 | 7-SUBSTITUTED CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS AND METHODS FOR PREPARING SAME | RES TRIANGLE INST (US) | 2011-11-30 | — | — | EP | disclosed |
| EP-1883407-A4 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | COMBINATORX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1638978-A4 | 7-SUBSTITUTED CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS AND METHODS FOR PREPARING SAME | RES TRIANGLE INST (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1883407-A1 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | CombinatoRx, Incorporated (US) | 2008-02-06 | — | — | EP | disclosed |
| US-20060264384-A1 | Compositions and methods for treatment for neoplasms | COMBINATORX, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006122007-A1 | COMPOSITIONS AND METHODS FOR TREATMENT FOR NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2006-11-16 | — | — | WO | disclosed |
| US-7067666-B2 | 7-substituted camptothecin and camptothecin analogs and methods for producing the same | RESEARCH TRIANGLE INSTITUTE (US) | 2006-06-27 | — | — | US | disclosed |
| EP-1638978-A2 | 7-SUBSTITUTED CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS AND METHODS FOR PREPARING SAME | RESEARCH TRIANGLE INSTITUTE (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050209263-A1 | 7-Substituted camptothecin and camptothecin analogs and methods for producing the same | RESEARCH TRIANGLE INSITUTE (US) | 2005-09-22 | — | — | US | disclosed |
| WO-2005009347-A2 | 7-SUBSTITUTED CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS AND METHODS FOR PREPARING SAME | RESEARCH TRIANGLE INSTITUTE (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20040266803-A1 | 7-Substituted camptothecin and camptothecin analogs and methods for producing the same | RESEARCH TRIANGLE INSITUTE | 2004-12-30 | — | — | US | disclosed |
| US-6653319-B1 | Formulating alkaline supersaturated aqueous solution of lipophilic derivative and solubilizer; acidifying | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2003-11-25 | — | — | US | disclosed |
| US-RE32518-E | Camptothecin derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1987-10-13 | — | — | US | disclosed |
| US-4399282-A | 7-HYDROXYALKYL DERIVATIVES USING FREE RADICAL CATALYSTS; ANTITUMOR AND -CARCINOGENIC AGENTS; NONTOXIC | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1983-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266803-A1 | 7-Substituted camptothecin and camptothecin analogs and methods for producing the same | TOP1, TOP2A, TOP2B | TOP1 1/4885MEN1 1687/4885KMT2A 2828/4885 |
| US-20240156808-A1 | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | TOP2A, TOP2B, TOP1 | TOP1 3/4885MEN1 601/4885KMT2A 1727/4885 |
| US-20060264384-A1 | Compositions and methods for treatment for neoplasms | MGMT, TP53, HCCS | TOP1 201/4885MEN1 71/4885KMT2A 1617/4885 |
| US-20050209263-A1 | 7-Substituted camptothecin and camptothecin analogs and methods for producing the same | TOP1, TOP2A, TOP2B | TOP1 1/4885MEN1 1687/4885KMT2A 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.