Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728688 | 0.90 | LSS (0.48) | LSSMCHR1KCNH2HRH3MAPT | |
| SCHEMBL1729124 | 0.89 | LSS (0.47) | LSSMCHR1KCNH2HRH3MAPT | |
| SCHEMBL1729760 | 0.89 | LSS (0.47) | LSSMCHR1KCNH2HRH3MAPT | |
| SCHEMBL1729087 | 0.86 | MAPK14 (0.51) | LSSMCHR1HRH3MAPK14 | |
| SCHEMBL6081167 | 0.86 | MCHR1 (0.42) | LSSMCHR1KCNH2HRH3ACACB | |
| SCHEMBL1729099 | 0.85 | MAPT (0.45) | LSSMCHR1KCNH2HRH3ACACB | |
| SCHEMBL6080844 | 0.85 | MCHR1 (0.41) | LSSMCHR1KCNH2HRH3ACACB | |
| SCHEMBL1727849 | 0.83 | KDM4E (0.43) | HRH3ACACB | |
| SCHEMBL1728856 | 0.81 | HRH3 (0.42) | MCHR1HRH3ADORA2AADORA2B | |
| SCHEMBL1727629 | 0.81 | LSS (0.47) | LSSMCHR1KCNH2HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |