Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728688 | 0.89 | LSS (0.48) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL6080844 | 0.88 | MCHR1 (0.41) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL1729124 | 0.88 | LSS (0.47) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL1729760 | 0.88 | LSS (0.47) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL1728571 | 0.86 | LSS (0.41) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL1729087 | 0.85 | MAPK14 (0.51) | MCHR1HRH3LSSMAPK14 | |
| SCHEMBL1729099 | 0.84 | MAPT (0.45) | MCHR1KCNH2HRH3LSSMAPT | |
| SCHEMBL6081904 | 0.83 | HRH3 (0.42) | HRH3KMT2AACACB | |
| SCHEMBL6081179 | 0.83 | HRH3 (0.41) | HRH3KMT2AACACB | |
| SCHEMBL1728856 | 0.80 | HRH3 (0.42) | MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |