Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729124 | 0.99 | LSS (0.47) | LSSMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL1729760 | 0.99 | LSS (0.47) | LSSMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL1729087 | 0.94 | MAPK14 (0.51) | LSSMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL1727629 | 0.91 | LSS (0.47) | LSSMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL1728571 | 0.90 | LSS (0.41) | LSSMCHR1MAPK14HRH3MAPT | |
| SCHEMBL6081167 | 0.89 | MCHR1 (0.42) | LSSMCHR1MAPK14HRH3MAPT | |
| SCHEMBL1729099 | 0.88 | MAPT (0.45) | LSSMCHR1HRH3MAPTKCNH2 | |
| SCHEMBL6080844 | 0.88 | MCHR1 (0.41) | LSSMCHR1MAPK14HRH3MAPT | |
| SCHEMBL1728814 | 0.87 | HTR2C (0.44) | MCHR1HRH3 | |
| SCHEMBL1727269 | 0.86 | HRH3 (0.42) | LSSMCHR1MAPK14HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |