Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17286122 | 0.83 | DYRK1A (0.55) | MAP4K4IDO1TDO2CYP17A1PSMB8 | |
| SCHEMBL17282296 | 0.75 | NFATC1 (0.44) | GSK3BDYRK1ASCN9A | |
| SCHEMBL12788367 | 0.72 | CYP17A1 (0.57) | MAP4K4CYP17A1PSMB8MAPKAPK2SREBF2 | |
| SCHEMBL4301854 | 0.71 | MAP4K4 (0.56) | MAP4K4CYP17A1PSMB8MAPKAPK2SREBF2 | |
| SCHEMBL31378805 | 0.71 | KCNQ3 (0.53) | CYP17A1MAPKAPK2NAMPT | |
| SCHEMBL535403 | 0.71 | KCNQ3 (0.53) | CYP17A1MAPKAPK2NAMPT | |
| SCHEMBL22418461 | 0.70 | FLT3 (0.62) | MAP4K4SRC | |
| SCHEMBL20865536 | 0.70 | CYP17A1 (0.68) | MAP4K4CYP17A1PSMB8CA12CA9 | |
| SCHEMBL23882424 | 0.70 | PDGFRA (0.47) | MAP4K4CYP17A1MAPKAPK2SREBF2NAMPT | |
| SCHEMBL30227622 | 0.70 | PDGFRA (0.47) | MAP4K4CYP17A1MAPKAPK2SREBF2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MAPT, SLC14A1, UBTF | MAP4K4 2904/4885IDO1 1939/4885TDO2 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.