Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.55 |
| ▸ | NFATC1 | O95644 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | BECN1 | Q14457 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15550098 | 0.83 | DYRK1A (0.63) | DYRK1ANFATC1GSK3BNAMPTS1PR1 | |
| SCHEMBL17286113 | 0.83 | MAP4K4 (0.45) | DYRK1AGSK3BCYP17A1NAMPTIDO1 | |
| SCHEMBL13459598 | 0.77 | CYP17A1 (0.54) | CYP17A1NAMPTPSMB8BCL2MAP4K4 | |
| SCHEMBL29096751 | 0.75 | CYP17A1 (0.60) | CYP17A1NAMPTPSMB8BCL2MAP4K4 | |
| SCHEMBL30230966 | 0.75 | CYP17A1 (0.60) | CYP17A1NAMPTPSMB8BCL2MAP4K4 | |
| SCHEMBL17282299 | 0.75 | IMPDH2 (0.53) | DYRK1ANFATC1GSK3BS1PR1S1PR3 | |
| SCHEMBL15548150 | 0.75 | SMN1; SMN2 (0.58) | DYRK1ANFATC1GSK3B | |
| SCHEMBL4759920 | 0.75 | CYP17A1 (0.79) | CYP17A1NAMPTPSMB8BCL2MAP4K4 | |
| SCHEMBL30231333 | 0.74 | CYP17A1 (0.59) | CYP17A1NAMPTIDO1PSMB8BCL2 | |
| SCHEMBL29096680 | 0.74 | CYP17A1 (0.59) | CYP17A1NAMPTIDO1PSMB8BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MAPT, SLC14A1, UBTF | DYRK1A 2261/4885NFATC1 3349/4885GSK3B 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.