Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CASP1 | P29466 | 3/20 | 0.54 |
| ▸ | CASP7 | P55210 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | RORA | P35398 | 2/20 | 0.50 |
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | RORB | Q92753 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17274752 | 0.92 | MAPT (0.64) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL29038434 | 0.81 | RORA (0.60) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL5527836 | 0.80 | TSHR (0.83) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL17274959 | 0.79 | MAPT (0.50) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL17274925 | 0.78 | MAPT (0.54) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL17274748 | 0.76 | POLB (0.56) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL18655577 | 0.76 | MAPT (0.67) | MAPTTSHRLMNACASP1CASP7 | |
| SCHEMBL29038442 | 0.76 | PGR (0.54) | MAPTLMNAPGRRORARORC | |
| SCHEMBL1335135 | 0.72 | PGR (0.73) | LMNATDP1PGRRORARORC | |
| SCHEMBL29531665 | 0.72 | PGR (0.73) | LMNATDP1PGRRORARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179218-A1 | AZA-ELLIPTICINE ANALOGS, METHODS OF SYNTHESIS AND METHODS OF TREATMENT | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2015-11-26 | — | — | WO | disclosed |