Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727580 | 0.97 | LMNA (0.46) | HPGDNPC1RAB9ASMN1; SMN2MCHR1 | |
| SCHEMBL1728662 | 0.85 | MCHR1 (0.47) | NPC1RAB9AMCHR1MEN1KMT2A | |
| SCHEMBL1728609 | 0.84 | MCHR1 (0.47) | HPGDMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL1729072 | 0.82 | MCHR1 (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1727554 | 0.82 | MCHR1 (0.49) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13903304 | 0.81 | MCHR1 (0.44) | NPC1RAB9ASMN1; SMN2MCHR1LMNA | |
| SCHEMBL1728688 | 0.80 | LSS (0.48) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1729124 | 0.79 | LSS (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1729760 | 0.79 | LSS (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13903321 | 0.77 | MAPK14 (0.40) | NPC1RAB9ASMN1; SMN2MCHR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |