Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728670 | 0.89 | STAT3 (0.46) | STAT3KAT6ASCN9A | |
| SCHEMBL1093963 | 0.81 | IDO1 (0.44) | STAT3 | |
| SCHEMBL20242456 | 0.80 | CA1 (0.44) | STAT3 | |
| SCHEMBL9959657 | 0.80 | STAT3 (0.43) | STAT3 | |
| SCHEMBL15258967 | 0.78 | SOS1 (0.37) | STAT3KAT6ASCN9A | |
| SCHEMBL9959654 | 0.76 | STAT3 (0.42) | STAT3 | |
| SCHEMBL15258969 | 0.75 | CA1 (0.39) | STAT3KAT6ASCN9A | |
| Formic Acid SCHEMBL19616984 | 0.75 | STAT3 (0.41) | STAT3KAT6A | |
| SCHEMBL14058255 | 0.74 | — | — | |
| SCHEMBL12482556 | 0.74 | CHRNA7 (0.35) | KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012113774-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-08-30 | — | — | WO | disclosed |
| EP-2406234-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104899-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-09-16 | — | — | WO | disclosed |