Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728666 | 0.89 | STAT3 (0.46) | STAT3KAT6ASCN9A | |
| SCHEMBL1093963 | 0.84 | IDO1 (0.44) | STAT3IDO1TDO2CA12CA1 | |
| SCHEMBL20242457 | 0.80 | CA2 (0.44) | STAT3CA12CA1CA2CA9 | |
| SCHEMBL9959654 | 0.79 | STAT3 (0.42) | STAT3IDO1TDO2CA12CA1 | |
| SCHEMBL18203769 | 0.79 | SCN9A (0.43) | KAT6ASCN9AIDO1TDO2 | |
| SCHEMBL15258969 | 0.78 | CA1 (0.39) | STAT3KAT6ASCN9AIDO1TDO2 | |
| Formic Acid SCHEMBL19616984 | 0.78 | STAT3 (0.41) | STAT3KAT6AIDO1TDO2CA12 | |
| SCHEMBL16947690 | 0.78 | — | — | |
| SCHEMBL9959657 | 0.77 | STAT3 (0.43) | STAT3CA12CA1CA2CA9 | |
| SCHEMBL25421181 | 0.76 | LRRK2 (0.40) | STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012113774-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-08-30 | — | — | WO | disclosed |
| EP-2406234-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104899-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-09-16 | — | — | WO | disclosed |