Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592915 | 0.81 | GRK2 (0.40) | HSP90AA1HSP90AB1NPC1RAB9AALDH1A1 | |
| SCHEMBL592914 | 0.76 | KMT2A (0.40) | HSP90AA1HSP90AB1NPC1RAB9AALDH1A1 | |
| SCHEMBL29950062 | 0.76 | NOTUM (0.41) | NOTUMIDH1 | |
| SCHEMBL2107339 | 0.76 | IDH1 (0.38) | IDH1 | |
| SCHEMBL6527480 | 0.74 | CYP11B2 (0.34) | — | |
| SCHEMBL8125549 | 0.74 | HDAC1 (0.35) | IDH1 | |
| SCHEMBL6675442 | 0.73 | MAOB (0.47) | NPC1RAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6098143 | 0.73 | CMA1 (0.36) | CMA1PTGS1IDH1 | |
| SCHEMBL590026 | 0.71 | F10 (0.56) | NPC1RAB9AKMT2AGRK2CTDSP1 | |
| SCHEMBL590024 | 0.71 | F10 (0.56) | NPC1RAB9AKMT2AGRK2CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146987-B1 | OXAZOLIDINONE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2015-12-02 | — | — | EP | disclosed |