Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL14125735 | 0.98 | TDP1 (0.61) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL309332 | 0.98 | TDP1 (0.61) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL28532084 | 0.93 | ALDH1A1 (0.61) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL6760441 | 0.93 | CES1 (0.56) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL27462973 | 0.93 | TDP1 (0.60) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL15203620 | 0.91 | ALDH1A1 (0.64) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL29806213 | 0.91 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL11048842 | 0.91 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL1839 | 0.91 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL5476151 | 0.90 | TSHR (0.55) | TDP1CES1CA1CA2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250269054-A1 | NANOPARTICLE DRUG CONJUGATES | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2025-08-28 | — | — | US | disclosed |
| CN-113082225-A | Nanoparticle drug conjugates | 纪念斯隆-凯特琳癌症中心 | 2021-07-09 | — | — | CN | disclosed |
| CN-106659797-B | Nanoparticle drug conjugates | 纪念斯隆-凯特琳癌症中心 | 2021-04-27 | — | — | CN | disclosed |
| US-20200289668-A1 | NANOPARTICLE DRUG CONJUGATES | CORNELL UNIVERSITY | 2020-09-17 | — | — | US | disclosed |
| EP-3693026-A1 | NANOPARTICLE DRUG CONJUGATES | Memorial Sloan Kettering Cancer Center (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3148591-B1 | NANOPARTICLE DRUG CONJUGATES | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2020-03-11 | — | — | EP | disclosed |
| US-20190070310-A1 | NANOPARTICLE DRUG CONJUGATES | MEMORIAL SLOAN KETTERING CANCER CENTER | 2019-03-07 | — | — | US | disclosed |
| US-10111963-B2 | Nanoparticle drug conjugates | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2018-10-30 | — | — | US | disclosed |
| CN-106659797-A | Nanoparticle drug conjugates | 纪念斯隆-凯特琳癌症中心 | 2017-05-10 | — | — | CN | disclosed |
| EP-3148591-A1 | NANOPARTICLE DRUG CONJUGATES | Memorial Sloan Kettering Cancer Center (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183882-A1 | NANOPARTICLE DRUG CONJUGATES | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2015-12-03 | — | — | WO | disclosed |
| US-20150343091-A1 | NANOPARTICLE DRUG CONJUGATES | MEMORIAL SLOAN KETTERING CANCER CENTER | 2015-12-03 | — | — | US | disclosed |