Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL14125735 | 1.00 | TDP1 (0.61) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL17289474 | 0.98 | TDP1 (0.59) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL27462973 | 0.95 | TDP1 (0.60) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL15203620 | 0.93 | ALDH1A1 (0.64) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL11048842 | 0.93 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL29806213 | 0.93 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL1839 | 0.93 | CES1 (0.58) | TDP1CES1CA1CA2ALDH1A1 | |
| P-Nitrophenol SCHEMBL5476151 | 0.92 | TSHR (0.55) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL64459 | 0.91 | ALDH1A1 (0.61) | TDP1CES1CA1CA2CES2 | |
| P-Nitrophenol SCHEMBL324522 | 0.91 | TSHR (0.61) | TDP1CES1CA1CA2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025128586-A1 | TRACELESS LINKER AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-06-19 | — | — | WO | claimed |
| WO-2024222870-A1 | ANTIBODY-DRUG CONJUGATE | 石药集团巨石生物制药有限公司 | 2024-10-31 | — | — | WO | claimed |
| JP-4574007-B2 | — | — | 2010-11-04 | — | — | JP | claimed |
| EP-1421956-B1 | Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide | APPLIED RESEARCH SYSTEMS (AN) | 2007-06-27 | — | — | EP | claimed |
| US-20070141620-A1 | POLYOL-IFN-BETA CONJUGATE AND COMPOSITION CONTAINING SAME | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-06-21 | — | — | US | claimed |
| EP-1421956-A1 | Process for stepwise attachment of polyethylene glycol (PEG) to a polypeptide | Applied Research Systems ARS Holding N.V. (AN) | 2004-05-26 | — | — | EP | claimed |
| US-20040043002-A1 | Polyol-IFN-beta conjugate and composition containing same | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2004-03-04 | — | — | US | claimed |
| JP-2002512983-A | — | — | 2002-05-08 | — | — | JP | claimed |
| EP-1075281-A2 | POLYOL-IFN-BETA CONJUGATES | Applied Research Systems ARS Holding N.V. (AN) | 2001-02-14 | — | — | EP | claimed |
| WO-1999055377-A9 | POLYOL-IFN-BETA CONJUGATES | APPLIED RESEARCH SYSTEMS (NL) | 2000-03-02 | — | — | WO | claimed |
| WO-1999055377-A2 | POLYOL-IFN-BETA CONJUGATES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 1999-11-04 | — | — | WO | claimed |
| US-20260124317-A2 | Antibody Drug Conjugates | BEONE MEDICINES I GMBH (CH) | 2026-05-07 | — | — | US | disclosed |
| WO-2025128586-A1 | TRACELESS LINKER AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-06-19 | — | — | WO | disclosed |
| CN-120131677-A | In-situ synthesis method of medicine and application thereof | 北京大学 | 2025-06-13 | — | — | CN | disclosed |
| US-20250135026-A1 | Antibody Drug Conjugates | BEIGENE SWITZERLAND GMBH (CH) | 2025-05-01 | — | — | US | disclosed |
| WO-1997033576-A1 | CARBAMYL GUANIDINE AND AMIDINE PRODRUGS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1996029304-A1 | NONPEPTIDES AS TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0730660-A1 | CHIMERIC PROTEINS INCLUDING PROTEASE NEXIN-1 VARIANTS | INCYTE PHARMACEUTICALS, INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5554641-A | Nonpeptides as tachykinin antagonists | WARNER-LAMBERT COMPANY | 1996-09-10 | — | — | US | disclosed |
| WO-1995011987-A1 | CHIMERIC PROTEINS INCLUDING PROTEASE NEXIN-1 VARIANTS | INCYTE PHARMACEUTICALS, INC. (US) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260124317-A2 | Antibody Drug Conjugates | SLC3A2, SLC7A1, SLC43A1 | TDP1 421/4885CES1 496/4885CA1 139/4885 |
| US-20250135026-A1 | Antibody Drug Conjugates | CD22, FCGR2A, FCGR3B | TDP1 3997/4885CES1 275/4885CA1 1067/4885 |
| US-20040043002-A1 | Polyol-IFN-beta conjugate and composition containing same | IFNG, IFNAR1, IL2 | TDP1 4231/4885CES1 3342/4885CA1 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.