Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.49 |
| ▸ | HRH1 | P35367 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 9/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27305141 | 0.78 | SLC6A2 (0.36) | HTR2AHRH1ALDH1A1DRD2HTR1A | |
| SCHEMBL13006642 | 0.78 | HTR2A (0.46) | HTR2AHRH1ALDH1A1MAPTHPGD | |
| SCHEMBL13560083 | 0.75 | ACE (0.47) | HTR2AHRH1ALDH1A1MAPTHPGD | |
| SCHEMBL14959494 | 0.72 | ACE (0.41) | HTR2AHRH1ALDH1A1TDP1DRD4 | |
| SCHEMBL11934336 | 0.71 | OPRD1 (0.41) | HTR2AHRH1ALDH1A1 | |
| SCHEMBL25686833 | 0.71 | MAPT (0.42) | MAPTDRD4SLC6A2SLC6A4 | |
| SCHEMBL11929939 | 0.69 | MEN1 (0.49) | HTR2AHRH1 | |
| SCHEMBL9815278 | 0.67 | SIGMAR1 (0.47) | HTR2AHRH1 | |
| SCHEMBL11860636 | 0.66 | HTR2A (0.79) | HTR2AHRH1ALDH1A1MAPTHPGD | |
| SCHEMBL11456556 | 0.65 | SLC6A2 (0.42) | HTR2AHRH1ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |