Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729245 | 0.92 | MEN1 (0.45) | MEN1KMT2ALMNAUSP2CYP1A2 | |
| SCHEMBL4780062 | 0.92 | EGFR (0.42) | MEN1KMT2ALMNAUSP2CYP1A2 | |
| SCHEMBL4781518 | 0.91 | ABCG2 (0.44) | MEN1KMT2ALMNAUSP2CYP1A2 | |
| SCHEMBL1729984 | 0.90 | ROCK2 (0.46) | MEN1KMT2ALMNAUSP2CYP1A2 | |
| SCHEMBL1729223 | 0.89 | ABCG2 (0.58) | MEN1KMT2ALMNATSHRMAPK1 | |
| SCHEMBL877821 | 0.86 | ROCK2 (0.45) | ABCG2ABCB1ERBB2EGFRERBB4 | |
| SCHEMBL1727988 | 0.85 | CYP1A2 (0.47) | MEN1KMT2ALMNAUSP2CYP1A2 | |
| SCHEMBL877621 | 0.85 | ROCK2 (0.45) | ABCG2ABCB1ERBB2EGFRROCK2 | |
| SCHEMBL877820 | 0.85 | ROCK2 (0.54) | MEN1KMT2AMAPK1CLK4ABCG2 | |
| SCHEMBL4779942 | 0.84 | CLK4 (0.44) | MEN1KMT2ALMNAUSP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |