Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | NEK4 | P51957 | 1/20 | 0.44 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780062 | 0.92 | EGFR (0.42) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL1729245 | 0.91 | MEN1 (0.45) | CLK4ROCK2EGFRMEN1KMT2A | |
| SCHEMBL4784662 | 0.91 | EGFR (0.43) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL4798787 | 0.90 | ROCK2 (0.46) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL3793329 | 0.89 | ABCG2 (0.54) | ROCK2EGFRITKTSHRABCG2 | |
| SCHEMBL877065 | 0.87 | EGFR (0.45) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL4783152 | 0.86 | EGFR (0.43) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL877114 | 0.86 | ABCG2 (0.45) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL877064 | 0.86 | ROCK2 (0.51) | CLK4ROCK2ROCK1EEF2KMAP4K4 | |
| SCHEMBL877115 | 0.84 | ABCG2 (0.47) | CLK4ROCK2ROCK1EEF2KMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |