Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17292975 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNANPC1USP2MEN1 | |
| SCHEMBL17293151 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNANPC1USP2MEN1 | |
| SCHEMBL31379341 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBRAB9AUSP2 | |
| SCHEMBL31379382 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBRAB9AUSP2 | |
| SCHEMBL17293189 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAPOLBNPC1MAPT | |
| SCHEMBL3712797 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBNPC1MAPT | |
| SCHEMBL12870626 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBNPC1MAPT | |
| SCHEMBL16409131 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBNPC1USP2TSHR | |
| SCHEMBL13135766 | 0.74 | LMNA (0.49) | SMN1; SMN2LMNAPOLBNPC1MAPT | |
| SCHEMBL9596202 | 0.74 | GBA2 (0.32) | SMN1; SMN2LMNAPOLBGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3149001-A1 | NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS | Novartis AG (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181747-A1 | NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS | NOVARTIS AG (CH) | 2015-12-03 | — | — | WO | disclosed |