Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712797 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBLMNANPC1MAPT | |
| SCHEMBL12870626 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2POLBLMNANPC1MAPT | |
| SCHEMBL13135766 | 0.81 | LMNA (0.49) | SMN1; SMN2POLBLMNANPC1MAPT | |
| SCHEMBL15561497 | 0.80 | RAB9A (0.50) | POLBRAB9AGAATSHRENPP2 | |
| SCHEMBL17293159 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBLMNANPC1MAPT | |
| SCHEMBL8141816 | 0.80 | FKBP1A (0.48) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL3656325 | 0.80 | FKBP1A (0.48) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL5727740 | 0.80 | FKBP1A (0.48) | SMN1; SMN2POLBLMNANPC1RAB9A | |
| SCHEMBL30278681 | 0.79 | CYP19A1 (0.44) | GAATSHRENPP2FKBP1ACA12 | |
| SCHEMBL16619795 | 0.79 | GBA2 (0.46) | SMN1; SMN2POLBLMNAGBA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3149001-A1 | NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS | Novartis AG (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181747-A1 | NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS | NOVARTIS AG (CH) | 2015-12-03 | — | — | WO | disclosed |