Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.69 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | AHCY | P23526 | 1/20 | 0.66 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.65 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294000 | 0.95 | PRKACA (0.69) | ADORA3ADORA2BADORA2AADORA1HSP90B1 | |
| SCHEMBL17293999 | 0.94 | PRKACA (0.73) | ADORA3ADORA2BADORA2AADORA1HSP90B1 | |
| SCHEMBL17297714 | 0.94 | PRKACA (0.73) | ADORA3ADORA2BADORA2AADORA1HSP90B1 | |
| SCHEMBL17294035 | 0.94 | PRKACA (0.75) | HSP90B1PRKACAROCK2AHCYMETTL3 | |
| SCHEMBL17294015 | 0.94 | PRKACA (0.75) | HSP90B1PRKACAROCK2AHCYMETTL3 | |
| SCHEMBL17294023 | 0.93 | PRKACA (0.73) | HSP90B1PRKACAROCK2AHCYMETTL3 | |
| Trifluoromethanesulfonic Acid SCHEMBL18730518 | 0.92 | ADORA3 (0.64) | ADORA3ADORA2BADORA2AADORA1HSP90B1 | |
| SCHEMBL17293992 | 0.92 | HSP90B1 (0.71) | ADORA3ADORA2BADORA2AADORA1HSP90B1 | |
| SCHEMBL17294024 | 0.91 | PRKACA (0.70) | HSP90B1PRKACAROCK2AHCYMETTL3 | |
| SCHEMBL17294011 | 0.91 | HSP90B1 (0.70) | ADORA3ADORA2BADORA2AADORA1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10077284-B2 | UBA5 inhibitors | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2018-09-18 | — | — | US | disclosed |
| US-20170107247-A1 | UBA5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-20 | — | — | US | disclosed |
| US-20170107247-A1 | UBA5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-20 | — | — | US | disclosed |
| WO-2015179955-A1 | UBA5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015179955-A1 | UBA5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10077284-B2 | UBA5 inhibitors | UBQLN2, UBTF, UBQLN1 | ADORA3 4605/4885ADORA2B 4493/4885ADORA2A 4363/4885 |
| US-20170107247-A1 | UBA5 INHIBITORS | UBQLN2, UBTF, UBQLN1 | ADORA3 4605/4885ADORA2B 4493/4885ADORA2A 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.