Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CTSH | P09668 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173045 | 1.00 | SIGMAR1 (0.38) | SIGMAR1DPP4GPR88ALOX5CTSK | |
| Hydrochloric Acid SCHEMBL3601756 | 0.98 | SIGMAR1 (0.37) | SIGMAR1DPP4GPR88ALOX5CTSK | |
| SCHEMBL12631992 | 0.82 | ANPEP (0.33) | — | |
| SCHEMBL10305516 | 0.79 | DPP4 (0.43) | SIGMAR1DPP4ALOX5 | |
| SCHEMBL3338713 | 0.78 | GPR88 (0.41) | DPP4GPR88ALOX5CTSKCTSL | |
| SCHEMBL3338710 | 0.78 | GPR88 (0.41) | DPP4GPR88ALOX5CTSKCTSL | |
| SCHEMBL3607510 | 0.78 | GPR88 (0.41) | DPP4GPR88ALOX5CTSKCTSL | |
| SCHEMBL12631588 | 0.77 | — | — | |
| SCHEMBL8271729 | 0.77 | CYP1A2 (0.40) | SIGMAR1 | |
| SCHEMBL3588546 | 0.76 | ANPEP (0.40) | DPP4GPR88ALOX5CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |