Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29726551 | 1.00 | S1PR1 (0.47) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295277 | 1.00 | S1PR1 (0.47) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17302191 | 0.88 | FAAH (0.57) | FAAHSMN1; SMN2LMNAHPGDCA9 | |
| SCHEMBL17295272 | 0.81 | FAAH (0.61) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295271 | 0.81 | FAAH (0.61) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295392 | 0.80 | PTPN1 (0.51) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295389 | 0.80 | PTPN1 (0.51) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295335 | 0.80 | FAAH (0.52) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17295336 | 0.80 | FAAH (0.52) | S1PR1S1PR3FAAHSMN1; SMN2LMNA | |
| SCHEMBL17302215 | 0.80 | CFTR (0.51) | S1PR1S1PR3FAAHSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |