Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.51 |
| ▸ | ACP1 | P24666 | 6/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 8/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295389 | 1.00 | PTPN1 (0.51) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17302191 | 0.90 | FAAH (0.57) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17295414 | 0.89 | ALDH1A1 (0.51) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17295415 | 0.89 | ALDH1A1 (0.51) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17302227 | 0.89 | PTPN1 (0.64) | PTPN1ACP1CA9CA2PTPN2 | |
| SCHEMBL17295441 | 0.84 | LMNA (0.49) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17295442 | 0.84 | LMNA (0.49) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17295269 | 0.83 | MAPT (0.52) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL17295268 | 0.83 | MAPT (0.52) | PTPN1ACP1FAAHLMNAHPGD | |
| SCHEMBL29726504 | 0.83 | MAPT (0.52) | PTPN1ACP1FAAHLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |