Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | FAAH | O00519 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295513 | 1.00 | MEN1 (0.61) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17295648 | 0.92 | MEN1 (0.61) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17295647 | 0.92 | MEN1 (0.61) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17302226 | 0.91 | FAAH (0.66) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17295397 | 0.91 | FAAH (0.66) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17295400 | 0.91 | FAAH (0.66) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL29726570 | 0.91 | FAAH (0.66) | MEN1ALDH1A1KMT2ANPSR1FAAH | |
| SCHEMBL17295406 | 0.88 | S1PR1 (0.61) | FAAHS1PR1S1PR3 | |
| SCHEMBL17295408 | 0.88 | S1PR1 (0.61) | FAAHS1PR1S1PR3 | |
| SCHEMBL17295272 | 0.88 | FAAH (0.61) | MEN1ALDH1A1KMT2ANPSR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |