Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295628 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17295415 | 0.92 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17295414 | 0.92 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL29726504 | 0.90 | MAPT (0.52) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17295269 | 0.90 | MAPT (0.52) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17295268 | 0.90 | MAPT (0.52) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17302191 | 0.87 | FAAH (0.57) | MAPTHPGDNPSR1MEN1KMT2A | |
| SCHEMBL17295444 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL17295448 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDNPSR1MEN1 | |
| SCHEMBL19096352 | 0.84 | ALDH1A1 (0.59) | ALDH1A1MAPTHPGDNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |