Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269710 | 0.81 | KEAP1 (0.58) | MAOAMAOBTAAR1ALDH1A1KEAP1 | |
| SCHEMBL18567782 | 0.79 | ALDH1A1 (0.47) | MAOAMAOBTAAR1SIGMAR1ALDH1A1 | |
| SCHEMBL16808970 | 0.79 | MAOB (0.89) | MAOAMAOBALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL18801048 | 0.78 | ALDH1A1 (0.52) | MAOAMAOBKMT2AALDH1A1KEAP1 | |
| SCHEMBL5694881 | 0.77 | TDP1 (0.54) | MAOAMAOBTAAR1ALDH1A1KEAP1 | |
| SCHEMBL2163306 | 0.77 | ALDH1A1 (0.61) | KMT2AALDH1A1KEAP1HDAC3MAPK1 | |
| SCHEMBL8605471 | 0.77 | ALDH1A1 (0.57) | TAAR1KMT2AALDH1A1ALOX5KEAP1 | |
| SCHEMBL16795814 | 0.74 | TDP1 (0.50) | MAOAMAOBTAAR1ALDH1A1KEAP1 | |
| SCHEMBL21321719 | 0.73 | FFAR1 (0.46) | ALDH1A1EGFRTSHRSLC6A3FFAR1 | |
| SCHEMBL12195215 | 0.73 | KEAP1 (0.54) | TAAR1KMT2AALDH1A1KEAP1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |