Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | PPARA | Q07869 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | TTR | P02766 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.62 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203843 | 0.85 | TSHR (0.68) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL4536166 | 0.84 | TSHR (0.59) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL18885323 | 0.81 | TSHR (0.62) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL5266458 | 0.80 | TSHR (0.70) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL15085817 | 0.80 | TSHR (0.60) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL4539546 | 0.79 | TSHR (0.65) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL12657603 | 0.79 | TSHR (0.65) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| Gemfibrozil SCHEMBL6033508 | 0.79 | PPARA (0.90) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL5929495 | 0.78 | TSHR (0.67) | TSHRPPARACYP2C9CYP2C8TDP1 | |
| SCHEMBL5673008 | 0.78 | TSHR (0.63) | TSHRPPARACYP2C9CYP2C8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158781-A1 | METHODS FOR PRACTICAL SYNTHESIS OF DEUTERATED AMINO ACIDS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-08-12 | — | — | WO | disclosed |
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20150344430-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | CATABASIS PHARMACEUTICALS, INC. | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344430-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | TSHR 2741/4885PPARA 196/4885CYP2C9 781/4885 |
| US-20170144972-A1 | METHODS OF LOWERING PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) | PCSK9, PCSK6, PCSK7 | TSHR 2741/4885PPARA 196/4885CYP2C9 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.