Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemfibrozil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 9/20 | 0.90 |
| ▸ | TSHR | P16473 | 3/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.90 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.90 |
| ▸ | TTR | P02766 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.90 |
| ▸ | PPARG | P37231 | 1/20 | 0.90 |
| ▸ | HTR2B | P41595 | 1/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.90 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.90 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.90 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.90 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.52 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemfibrozil SCHEMBL1880616 | 0.95 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL20770039 | 0.95 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL4813 | 0.95 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL29398115 | 0.95 | PPARA (1.00) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL10542601 | 0.93 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL21052128 | 0.93 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| Gemfibrozil SCHEMBL457931 | 0.93 | PPARA (0.97) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL21992001 | 0.88 | PPARA (0.86) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL6678081 | 0.83 | PPARA (0.79) | PPARATSHRCYP2C9CYP2C8TTR | |
| SCHEMBL9481043 | 0.83 | PPARA (0.79) | PPARATSHRCYP2C9CYP2C8TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660017-A2 | AMINO ACID PRODRUGS | Signature R&D Holdings, LLC (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005046575-A2 | AMINO ACID PRODRUGS | SIGNATURE R & D HOLDINGS, LCC (US) | 2005-05-26 | — | — | WO | disclosed |