Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17303160 | 0.88 | TP53 (0.52) | ALDH1A1KDM4EHSD17B10TP53NPC1 | |
| SCHEMBL31704361 | 0.78 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10MAPK1TP53 | |
| SCHEMBL22121772 | 0.76 | GRM2 (0.38) | ALDH1A1KDM4EHSD17B10MAPK1TP53 | |
| SCHEMBL30804003 | 0.75 | CSNK1D (0.36) | ALDH1A1KDM4EHSD17B10MAPK1HPGD | |
| SCHEMBL10532301 | 0.74 | NPC1 (0.55) | ALDH1A1KDM4EHSD17B10TP53NPC1 | |
| SCHEMBL30568579 | 0.73 | HRH4 (0.35) | ALDH1A1KDM4EHSD17B10MAPK1NPC1 | |
| SCHEMBL3108835 | 0.73 | NPC1 (0.54) | ALDH1A1KDM4EHSD17B10TP53NPC1 | |
| SCHEMBL13750723 | 0.73 | RAB9A (0.54) | ALDH1A1KDM4EHSD17B10MAPK1TP53 | |
| SCHEMBL14076027 | 0.73 | NPC1 (0.54) | ALDH1A1KDM4EHSD17B10TP53NPC1 | |
| SCHEMBL10766823 | 0.73 | NPC1 (0.50) | ALDH1A1KDM4EHSD17B10TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604989-B2 | Imidazopyridazines as Akt kinase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-28 | — | — | US | claimed |
| US-20150368250-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-24 | — | — | US | claimed |
| US-9206185-B2 | Imidazopyridazines as Akt kinase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368250-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | PI4KA, PI4KB, PIK3CD | ALDH1A1 1629/4885KDM4E 2256/4885HSD17B10 1802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.