Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2529018 | 0.88 | DRD4 (0.52) | DRD4DRD2DRD3KCNH2APP | |
| SCHEMBL24854638 | 0.87 | KCNA3 (0.46) | DRD4DRD2DRD3APPLTA4H | |
| SCHEMBL28379819 | 0.86 | ALDH3A1 (0.53) | DRD4DRD2DRD3KCNH2APP | |
| SCHEMBL1345118 | 0.85 | MAOB (0.57) | DRD4DRD2DRD3KCNH2APP | |
| SCHEMBL28455343 | 0.85 | HRH3 (0.53) | DRD4DRD2DRD3KCNH2ALDH3A1 | |
| SCHEMBL11564401 | 0.85 | HRH3 (0.53) | DRD4DRD2DRD3KCNH2ALDH3A1 | |
| SCHEMBL9770319 | 0.82 | DRD4 (0.59) | DRD4DRD2DRD3KCNH2SMN1; SMN2 | |
| SCHEMBL9770302 | 0.82 | ALDH3A1 (0.62) | DRD4DRD2DRD3KCNH2SMN1; SMN2 | |
| SCHEMBL1777301 | 0.81 | DRD4 (0.48) | DRD4DRD2DRD3KCNH2APP | |
| SCHEMBL4618802 | 0.80 | APP (0.52) | DRD4DRD2DRD3KCNH2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019191410-A1 | INHIBITORS FOR THE Β-CATENIN / T-CELL FACTOR PROTEIN–PROTEIN INTERACTION | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
| WO-2015184349-A2 | MULTIVALENT RAS BINDING COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-12-03 | — | — | WO | disclosed |