Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17306718 | 0.94 | CYP19A1 (0.48) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17307079 | 0.93 | CYP19A1 (0.47) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17307023 | 0.92 | CYP19A1 (0.55) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17306756 | 0.90 | PIK3CA (0.51) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17306683 | 0.90 | CYP2A6 (0.48) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17306760 | 0.90 | CYP2A6 (0.48) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17307061 | 0.89 | CYP1A2 (0.46) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17307063 | 0.88 | CYP2A6 (0.49) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17306710 | 0.88 | CYP1A2 (0.45) | CYP19A1DHODHCLK4CHEK1AURKA | |
| SCHEMBL17306686 | 0.88 | CYP1A2 (0.45) | CYP19A1DHODHCLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015182769-A1 | QUINAZOLINE AND BENZOQUINAZOLINE COMPOUNDS AND PRODUCTION AND USE OF SAME | 東ソー株式会社 | 2015-12-03 | — | — | WO | disclosed |