Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17306718 | 0.96 | CYP19A1 (0.48) | PIK3CAMKNK1CYP19A1CYP17A1CYP11B1 | |
| SCHEMBL17307079 | 0.95 | CYP19A1 (0.47) | PIK3CAMKNK1CYP19A1CYP17A1CYP11B1 | |
| SCHEMBL17306755 | 0.94 | MAPT (0.47) | PIK3CAMKNK1CYP1A2CYP3A4LMNA | |
| SCHEMBL17307066 | 0.92 | MAPT (0.45) | PIK3CAMKNK1CYP1A2CYP3A4LMNA | |
| SCHEMBL17307089 | 0.92 | MKNK1 (0.52) | PIK3CAMKNK1RAF1MAP4K4ALDH1A1 | |
| SCHEMBL17306700 | 0.92 | MKNK1 (0.52) | PIK3CAMKNK1RAF1MAP4K4ALDH1A1 | |
| SCHEMBL17306569 | 0.91 | HPGD (0.48) | PIK3CAMKNK1CYP19A1CYP17A1CYP11B1 | |
| SCHEMBL17307061 | 0.91 | CYP1A2 (0.46) | PIK3CACYP19A1CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL17306624 | 0.90 | CYP19A1 (0.56) | PIK3CAMKNK1CYP19A1CYP17A1CYP11B1 | |
| SCHEMBL17306686 | 0.90 | CYP1A2 (0.45) | PIK3CACYP19A1CYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015182769-A1 | QUINAZOLINE AND BENZOQUINAZOLINE COMPOUNDS AND PRODUCTION AND USE OF SAME | 東ソー株式会社 | 2015-12-03 | — | — | WO | disclosed |