Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21233484 | 0.94 | PTPN1 (0.37) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL19223309 | 0.92 | PTPN1 (0.35) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL17307932 | 0.85 | TSHR (0.42) | TDP1TSHRLMNACYP1A2CYP2C19 | |
| SCHEMBL13641684 | 0.78 | TSHR (0.51) | TSHRLMNATHRB | |
| SCHEMBL8740819 | 0.78 | TSHR (0.51) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL21422393 | 0.77 | PTPN1 (0.46) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL21422384 | 0.77 | PTPN1 (0.48) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL21422479 | 0.77 | ADRB2 (0.37) | TDP1POLBAPEX1HTTTSHR | |
| SCHEMBL19223358 | 0.77 | TSHR (0.35) | TDP1TSHRHDAC3HDAC1HDAC2 | |
| SCHEMBL13577800 | 0.75 | ESR1 (0.47) | TDP1TSHRLMNACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9532931-B2 | Polysiloxane compound and dental materials that can be prepared from it | VOCO GMBH (DE) | 2017-01-03 | — | — | US | disclosed |
| US-20150342841-A1 | POLYSILOXANE COMPOUND AND DENTAL MATERIALS THAT CAN BE PREPARED FROM IT | VOCO GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150342841-A1 | POLYSILOXANE COMPOUND AND DENTAL MATERIALS THAT CAN BE PREPARED FROM IT | SMCHD1, IPO5, IPO9 | TDP1 2478/4885POLB 950/4885APEX1 3091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.