Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.45 |
| ▸ | CDK2 | P24941 | 11/20 | 0.45 |
| ▸ | CCND1 | P24385 | 8/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.41 |
| ▸ | CDK9 | P50750 | 5/20 | 0.41 |
| ▸ | CDK4 | P11802 | 5/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15829847 | 0.83 | POLB (0.48) | CCNE1CDK2CCND1CDK6IDO1 | |
| SCHEMBL19633397 | 0.81 | FABP6 (0.50) | MEN1GAATSHRKMT2ANPSR1 | |
| SCHEMBL17303771 | 0.80 | TSHR (0.64) | MEN1GAATSHRKMT2ANPSR1 | |
| SCHEMBL21297244 | 0.80 | MAPT (0.52) | MEN1GAATSHRKMT2ANPSR1 | |
| SCHEMBL18466153 | 0.80 | IDO1 (0.48) | CCNE1CDK2CCND1CDK6IDO1 | |
| SCHEMBL19633739 | 0.80 | MEN1 (0.45) | MEN1KMT2ACCNE1CDK2CCND1 | |
| SCHEMBL16220685 | 0.76 | KDM4E (0.40) | — | |
| SCHEMBL17072662 | 0.75 | MAPK1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL28306630 | 0.75 | IDO1 (0.53) | IDO1FABP6 | |
| SCHEMBL16220941 | 0.74 | HRH3 (0.46) | MEN1GAATSHRKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344434-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344434-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | MEN1 1626/4885GAA 3431/4885TSHR 4109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.